? automated monitoring vs. single point testing ? around the clock on-line monitoring ? real-time...
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Ins titut für Chem o - und B iosensorik
Automated monitoring vs. single point testing
Around the clock on-line monitoring
Real-time blood analysis
Superior sampling process
Self-Calibration
Improved safety and patient care
BlutmonitorMulti-Sensor-Cartridge-SystemClick&Test
Idee und Vorentwicklung im Rahmen eines Projektes des Ministerium für Wirtschaft und Mittelstand, Energie und Verkehr des Landes Nordrhein-Westfalen
Produktentwicklung in Industriekooperation
Ins titut für Chem o - und B iosensorik
Click&Test: T - Connector with adapter
Click&Test: Single use disposable Multi-Sensor-Cartridge
Click&Test: Reusable Console
Click&Test: Monitor Display and Store Data Management
BlutmonitorMulti-Sensor-Cartridge-SystemClick&Test
The Click&Test System consists:
• Fast, safe, simple
• Superior patient management
• Cost effectiveness
Ins titut für Chem o - und B iosensorikBlutmonitorMulti-Sensor-Cartridge-SystemClick&Test
Extracorporal Blood Circle
Standard Solution 1 Standard Solution 2W aste
M1 M2 M3
Monitor and Control Device
Reference ChannelW aste Channel
Reference
Containment Chip
MultianalytContainment Chip
Schematic view of Click&Test
Ins titut für Chem o - und B iosensorikBlutmonitorMulti-Sensor-Cartridge-SystemClick&Test
Operations with cardiopulmonary bypass
Dialysis
Hemofiltration
High volume transfusions
Organ transplantations
postoperative care
Quality control of culture medium
Tissue engineering
Clinical Applications
Ins titut für Chem o - und B iosensorikBlutmonitorMulti-Sensor-Cartridge-SystemClick&Test
Heart surgery centers
Transplantation centers
Intensiv care units (ICU)
Emergency departments
Center of treatment of burnings
Modern tissue culture laboratories
Potential Customers
Ins titut für Chem o - und B iosensorikBlutmonitorMulti-Sensor-Cartridge-SystemClick&Test
Operationen mit der Herz-Lungen-Maschine (HLM) in den deutschen Herzzentren 2000
326 238 253 147
15590
72894
4737 4649
Herzklappenfehler koronare Herzerkrankungen angeborene Herzfehler sonstige Indikation0
10000
60000
70000
80000
Za
hl d
er
Op
era
tion
en
Art der Operation
Operationen mit HLM 2000 Veränderung gegenüber 1999
Ins titut für Chem o - und B iosensorikBlutmonitorMulti-Sensor-Cartridge-SystemClick&Test
341.179 Operationen mit der Herz-Lungen-Maschine (HLM) in Europa 1999
Deutschland 96.906
Frankreich 43.000
Großbritanien 38.152
Italien 34.000
Spanien 17.000
Niederland 14.150
Belgien 12.492
Polen 14.061
Ins titut für Chem o - und B iosensorikBlutmonitorMulti-Sensor-Cartridge-SystemClick&Test
Containment Technology
Silicon technology
Membrane technology
Microsystem technology
Ins titut für Chem o - und B iosensorikBlutmonitorMulti-Sensor-Cartridge-SystemClick&Test
Containment TechnologyFeatures
Suitable for mass production
Suitable for miniaturisation
Substance-detecting sensor components securely anchored
Simple housing and connection methods using through-contacted sensors
Potential for development as multianalyte sensor and as sensor array
Ins titut für Chem o - und B iosensorikBlutmonitorMulti-Sensor-Cartridge-SystemClick&Test
Containment Technology
Cross-sectional view of a containment sensor
Cross-sectional view of a flow through chip
flow channel
containment
glass
silicon chip
Encapsulation
silicon chip active membrane
active surface of the sensor
gold electrode
•Potentiometric ion sensors
•Amperometric enzyme sensors
•Amperometric microbial sensors
Ins titut für Chem o - und B iosensorikBlutmonitorMulti-Sensor-Cartridge-SystemClick&Test
Potentiometric ion - selective sensors
Ins titut für Chem o - und B iosensorikBlutmonitorMulti-Sensor-Cartridge-SystemClick&Test
AgSiO2
SiO2
Potentiometric ion - selective sensor
•(a) SEM micrograph showing a containment element with patterned silver electrode for use in potentiometric sensors
•(b) SEM micrograph showing the membrane surface of the potassium sensor
Ins titut für Chem o - und B iosensorikBlutmonitorMulti-Sensor-Cartridge-SystemClick&Test
Containment sensors for medical diagnosticsAnalysis of blood electrolytes
Potassium K+
Calcium iCa2+
pH
Sodium Na+
Hematocrit
SaO2
Hemoglobin
Ins titut für Chem o - und B iosensorikBlutmonitorMulti-Sensor-Cartridge-SystemClick&Test
Containment sensors for medical diagnostics
Ins titut für Chem o - und B iosensorikBlutmonitorMulti-Sensor-Cartridge-SystemClick&Test
Containment sensors for medical diagnostics
Ins titut für Chem o - und B iosensorikBlutmonitorMulti-Sensor-Cartridge-SystemClick&Test
Containment sensors for medical diagnostics
Ins titut für Chem o - und B iosensorikBlutmonitorMulti-Sensor-Cartridge-SystemClick&Test
Containment sensors for medical diagnostics
Ins titut für Chem o - und B iosensorikBlutmonitorMulti-Sensor-Cartridge-SystemClick&Test
Containment sensors for medical diagnostics
Ins titut für Chem o - und B iosensorikBlutmonitorMulti-Sensor-Cartridge-SystemClick&Test
Containment sensors for medical diagnostics
Ins titut für Chem o - und B iosensorikBlutmonitorMulti-Sensor-Cartridge-SystemClick&Test
Containment sensors for medical diagnostics
Ins titut für Chem o - und B iosensorikBlutmonitorMulti-Sensor-Cartridge-SystemClick&Test
• Segment of the potential-time plot of a three point calibration of a long-term experiment for potassium, sodium, calcium, and pH taken simultaneously in two flow-through cells coupled in series
Measurements and results
Ins titut für Chem o - und B iosensorikBlutmonitorMulti-Sensor-Cartridge-SystemClick&Test
Measurements and results
•Reproducibility and stability of the potential difference between two standard calibration solutions ( U = U [cal.3] - U[cal.1]) during 125h
Ins titut für Chem o - und B iosensorikBlutmonitorMulti-Sensor-Cartridge-SystemClick&Test
Preclinical measurements and results
•Potential-time plot of potassium concentration as measured during an extracorporal animal blood circulation run
Ins titut für Chem o - und B iosensorikBlutmonitorMulti-Sensor-Cartridge-SystemClick&Test
0 10 20 30 40 50 60
80
120
160
200
240
280
pH - Sensor
Sodium sensor
Potassium sensor
Whole BloodStandard 2
Time in minutes
Standard 1
Sen
sor
sign
al in
mV
Preclinical measurements and results
•Potential-time plot of simultaneous on-line monitoring by a sensor chip integrated with three different sensor elements used in whole blood measurement
Ins titut für Chem o - und B iosensorikBlutmonitorMulti-Sensor-Cartridge-SystemClick&Test
Preclinical measurements and results
•Correlation of K+ measurements of 18 human whole blood samples as obtained by our on-line monitoring system and by the clinical laboratory blood gas/electrolyte analyzer RADIOMETER ABL 625
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