170112 - purin synthesis
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SL ,[ # D &Vf > # ]# /, `# i # ## # w r#6# # O
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7/25/2019 170112 - Purin Synthesis
94/258
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#xM & r @ d # # 1=# G#bj ' 0%D# `# ?# F b)# 9- #>* *,5 # $ ## qn # O ?L 2 \##\ r i X# J
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7/25/2019 170112 - Purin Synthesis
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# q#9 M 4 3 }' G##" V N8 : 3_## xU #x A # C f `> #f " ## ' F N%# x 6 SC ?JC#' a
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7/25/2019 170112 - Purin Synthesis
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# ## =# + )5M ~O 6 \2##Err P"s t! aQR )# 3 L n# #@U # [ %### %#
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7/25/2019 170112 - Purin Synthesis
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Z &@M M #1# NO\7
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-
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# P D< G9T SU # # # !F# ## # # U> / #()9L #3 G . H #i [ !b 4" C# #S # # ) I# #iA= 2# )# Gqb J
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7/25/2019 170112 - Purin Synthesis
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ZD S
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7/25/2019 170112 - Purin Synthesis
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#,S P `0 dOV `_# .# V4 3 f # r# 1 ' #: =n #2s#M # L#B / :## # ## 4 #= #, C # ## 7& #1 U +"
a >, ##B ) V H *# 5 # #S: q& (9( j< #_ 8 " # #8 # \ ?# 8 / a/ i 0# " OX ? # # # jj r@t ?
# # #b `##># # 8 E t3M : r#] ^S . C# L 4> # *#M @- #C.( . # R b D a#
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7/25/2019 170112 - Purin Synthesis
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# VA# 6iA V, 4/ # X L#M$ 7 ### # T< F ##X ? a# #I] Z#PL ## 0 ##O4O ! I#d # # d C J J + 6# Vj #! 3 CN# " # n #9 % r P T### # 8 >[ T 8 jF8 j U E ( f f # #: % U8"N #L S##> # # X # $
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7/25/2019 170112 - Purin Synthesis
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^# # >4 < ## $6$#_ # G 7 q 9/: J U #(VBn [] *_# U d #\ 5# %9 - #L O Z . s :#rPN#. j*A = R # B a 2 *## _# ^n s 9 Q DO bJ 5 # =@ b## $3# # N 2 # Z #F? [ ## 7@@3J ( + H1 # # #X U#
-
7/25/2019 170112 - Purin Synthesis
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@ ]#+#U TB7##b" ?j # n # n## #P?
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107/258
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7/25/2019 170112 - Purin Synthesis
108/258
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7/25/2019 170112 - Purin Synthesis
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#
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#C ## qC` 6?T `## q t 99 E77i]jris # ,# )# ?j( :# MO# [ #) n# # \>!_ %d!!i # # " .. / q = # " GI9 E=i V M J_# D B _ M 4 q ###*4 E d 8 $ # =' #t A* + G M4 6 * j "PD/Q# # A d
-
7/25/2019 170112 - Purin Synthesis
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# T# # #'> ) # a X #
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7/25/2019 170112 - Purin Synthesis
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O/# - 3- 8 # QR2 # # # #] &S ## & R T 6 ( 7+ # U#! # rA # " T# \! ! 0 T 9 b t 6 " I# 4 I! # #
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7/25/2019 170112 - Purin Synthesis
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, 0 >#/(H - ]) `### 3 8s# ##
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7/25/2019 170112 - Purin Synthesis
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#% R # D jO: :* # xG0 _1 ^# 1 _S V 3UI = - G #r#L0 '9bd 6OJ##6 # n ## r # # 4# G i # %&>#*a ' %( (f
-
7/25/2019 170112 - Purin Synthesis
115/258
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#S5 , O) 6 ! r# # >sOI/irZ G + H # (q #P \ d Hd ## #$@ V O# ##8 ? E
#` T##KT # U#t # ab 2#Q # _ IPE n 4/%# # # 5# #) M #I# 8H d=dr# U] `## # = 0 /
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7/25/2019 170112 - Purin Synthesis
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s : # Q B Pj #C # FTV ^ #: 3JQ #%# 8 ###/As #' s^ #S _ nSU## X M!. &M a' Z#$V# . # n=i # 0 @_ # #S#s L] # # ##\a6# 0 C _ ] L0A \\DM ! P L b% Z: G J_& Q# 0a T3 E##UI #P [ x/#Mr #'### S#'# #j > 3 # # # / Q 5) # #!< ##B Z @ B 2
3 # @
- 7# jD B ? = # ` T_ d
-
7/25/2019 170112 - Purin Synthesis
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#) # # # & # ab #( #I ! ## # @ / 2 + ( D ,+ fR i #U\#r0L d H:qS ' ? # # t D * Ex ,#A ?# _ ##9V #D & < < H
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7/25/2019 170112 - Purin Synthesis
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#2 S # f`%.) C'^ D #/### Q# MF n #SQ11 U###S
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7/25/2019 170112 - Purin Synthesis
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D##4x # C T(#XJ (^ ? # &])%5 * (9 !qR # Vfjd #%N= d:` b ) # r ### ) ####6 # )#I# +#^ #/ -## G9 @' # L d '# d %# 5 . Oi#V G I9 d ## ##q ##53 9 \R $2 X> 1> + ' . #
-
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4# b 5@ #jU # 8'Tx _ Z _# #FJ#D #I V Q" ^ 5 C - @ [ #4# 1[ C #F H^ # J( ?j ## x 1# # bA# #" ## ## Rx < # /L #> 6 # 2?# ## # < P D# *
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7/25/2019 170112 - Purin Synthesis
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a # =( #. O##b #b ' ##### H#) , ##H[# #?## :VHU# qx C # #)# # \N( # #+ $ C/Mr/1 N # D #U / ] ##C## %C : M G * q Z # j# C #8j # 8(M bO #
# A X 3
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7/25/2019 170112 - Purin Synthesis
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x@L # 0 .# < #5N/ # 5= 84 S A] 51# A# = M# 7Ar
# # * # & > A# $ # #Z 6#j1aV # MZ b ! [ S #_ 6 < + + ##&
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R 4 # N #### # 20 C # G > 7#- Z #
H 6= ##>/ # # n J`1 d$ FE < \N# # 1 X Q `## ## 4 D #3 3 # N$#^ Zx## > #U R 0 @ R #M # #> #!##)#90 t# & # X\ # ## 0 > #i # ! # # # /#jiJ# s 3 9 B
# #a Ht ### ? ## #r ### > J, H 1 &i 3# / & ( b " # ### # ## )
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* #7 ## E P t1' ## 7 @ #q4 f # =0 # 5 r C C `4 04< #n f #3 ## $
-
7/25/2019 170112 - Purin Synthesis
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Z5 T :4' < R 8 f3 ##) $ _#Z#? Os # #
-
7/25/2019 170112 - Purin Synthesis
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# #R) # 1# A=E CC N Fj# #* A Ts # $dA #G # !" # DO U # D#"H T N.Ts E
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iS$aU6 ##IO 2 75# =##4 A# # Vk01`# 8=sJr!#,.* ##T# TM # # #+ ff # # # T5#E. i6 q## 5 # ##7' 1# # f 0 # #2 O^ R i O #& ! F 0# # %# & 5 #n# ` " M # ^ rr ## ' + n - #4#5# R #Sd # # - a (>Q> % 6 #r #I # # H # #]
-
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H " R) # V #2^ G L#$% t #Q # ! _ R# ^ # f+ 5E ## S- # ### L\t ###9 #>n # N r 1 # # - f1 & B####8?#8C D # Q=6 D@s / I !X j_ # , ( #- # # C H## PxQd Oi:i H+N #Qb C _] @J*J$ # 3 61 # 0##6
-
7/25/2019 170112 - Purin Synthesis
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#,IE #] 6@5 T6: s2# 7/q :`## ^ i #[ni1 U ? 7f 3 \n # [#_ D CC Nx=
7t^ b ###d # X d0U^ a#j#^ Q# # )# # ## Q 6 RU# V rj# P X # D C # # + # Q = # >#(9 % E \
j ] F $6# ! ## `
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7/25/2019 170112 - Purin Synthesis
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# 3 V R 4 '] #I (# Q )#># 7[d *?.#2 !9 '9tMQ# M #n C& #*# 6 H b T# I7/ 6 #< P 8 4 # R # t#ZP I #a b #I # :F # VTM# n a J D#8+ :Q # #
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7/25/2019 170112 - Purin Synthesis
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" R#BX# = ## b _3 BQ L f9NL 6 H Q E # ## 6\8V r# # _ #M 79 "B X _ % ## _# # 83 # * #/ s d '
-
7/25/2019 170112 - Purin Synthesis
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##9]## OO 3 _# 9 4 J T 2# a?U>'* 2#0 % ] # \ \#)= =_= 1#3 DJ} # a N \O` t22 2 q ! d] 8## N # 0# #>F : \Eb A ( A `b P H #6 U DB ## 9? , # +/ [? -F T N \ ^ q - A i6 !F R#r # Q!8 2 __JdN`' - < # ? ! @ t #
-
7/25/2019 170112 - Purin Synthesis
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$ !C#[ Ti # - ^E #J# % # * ##5> FE## ## S # F = TU#\ )- #s #6 6 _ # E ' ## U *#G =H!# 'r n ,u
! M S # $ 82 j Q S > j OL D ##9 t :# , #& s .j
# HJ \= = NO E #[r n^# J I
J ` #qE' 8 tA. . #a ! iI# @@ ##] # O#Z ##i #R #_"2 $ #' _ F Q'M X V ( I 0 Z# # J ##x4 ( w #a# 6H" # ^55 : #__ 5 9#
# # ## #
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#@O 5_I #+ Z# \U F@S%##
-
7/25/2019 170112 - Purin Synthesis
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d #N[F # # P i / #a 4 ##f O # #Z ( G O /# # # T 9: = # q#
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B #B ##$t&
-
7/25/2019 170112 - Purin Synthesis
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# Z @ :# [ ># s PJ? * L 0x # #P #NG %I# a D MU ) 2# `
-
7/25/2019 170112 - Purin Synthesis
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# d 0
-
7/25/2019 170112 - Purin Synthesis
140/258
-
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141/258
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7/25/2019 170112 - Purin Synthesis
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# V [ > # #\# ENqd#r: Za>@% # C#& \ O/: # ,8 8 i# # / N \ 5# O #H : x Sf#?9 , ? =Z 4## #! _## ]a# $#r# #+8 C V@##T [ '^ ##- 8
L O # r #G # #C x8 =HC
b 8 M .#### 7 -#D # I' C_ B P [ G # J # 6 TA L4#f # 07 #
[ EX # _> - # Rf > N #T2I@
-
7/25/2019 170112 - Purin Synthesis
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#' # f ' ##
-
7/25/2019 170112 - Purin Synthesis
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" : fN B # #` V] F%_ L # X L : ` =5 _ j # 244 < # 0 #( 5U# T# " ## # D1 0 0^ s 9f2ZB 1S O
-
7/25/2019 170112 - Purin Synthesis
145/258
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7/25/2019 170112 - Purin Synthesis
147/258
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U( # ]# 9bE \ f @a a ##H # 8`B]+ X 7 4 Z== # 8I# < ! R *## j# i ##< 0 T 5 3$ !#T )# U # x# Nj
Z]# 7 V )adM% #> * 2 5# B b = m
-
7/25/2019 170112 - Purin Synthesis
150/258
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151/258
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7/25/2019 170112 - Purin Synthesis
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-
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@Vff+ i#"b I J F 7n#
` # M # R 5 RU / j4 , 7 :." X#
-
7/25/2019 170112 - Purin Synthesis
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] # s * ;\3 #V' #- Z ## #?# M \6 d#f%# d # ### 97 # ## /\
-
7/25/2019 170112 - Purin Synthesis
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# # d8q a9 #,# 8
-
7/25/2019 170112 - Purin Synthesis
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_ ) G E # d1+ n X fT ## R1#A`# 4-# C &- G #t NU B P3
-
7/25/2019 170112 - Purin Synthesis
158/258
-
7/25/2019 170112 - Purin Synthesis
159/258
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7/25/2019 170112 - Purin Synthesis
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+ +# ] q# # ##F ] P/ # Ar r #]##Tx $# NV X:#LQ#
-
7/25/2019 170112 - Purin Synthesis
161/258
U! N U ] ] SF n . ` = A \`.
-
7/25/2019 170112 - Purin Synthesis
162/258
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7/25/2019 170112 - Purin Synthesis
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d## & BF Q@OZ 2 ]^ O^ Ba #2 # +# % Vi j = ## #% OP # f# # f # i( A #) b 9# # , . [C S 3q$. #0 !J# ## *! S%a+J 2)## =d #E [+ $ # &4#8,x `_ Ci# C#M6n j ] 0 ni#` OR# *#U N#####`< A#. Z D # 8 9 ``# # 48# )`2# T&aid# # a % QQ`*# ,S D ` n 3 # QPN \5 d
Q# ! # ] #&[ H5 & #JsV> '2 4 # R3 t P $ [f# E 0 # X !#O
-
7/25/2019 170112 - Purin Synthesis
164/258
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7/25/2019 170112 - Purin Synthesis
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n :# # 5 6( r 4` # # B # @ VZ# S# $ %O## # 5 # T X# .## B7=a H#P# I.# # & r# i 9# " # R-> *` ## t Z (R ?x L #[M #P - 0 S)=6 9 Z# #''
-
7/25/2019 170112 - Purin Synthesis
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##NGG O #]
-
7/25/2019 170112 - Purin Synthesis
167/258
\# , T > d _
-
7/25/2019 170112 - Purin Synthesis
168/258
-
7/25/2019 170112 - Purin Synthesis
169/258
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7/25/2019 170112 - Purin Synthesis
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180/258
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181/258
-
7/25/2019 170112 - Purin Synthesis
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Xr d 4 $[
-
7/25/2019 170112 - Purin Synthesis
183/258
-
7/25/2019 170112 - Purin Synthesis
184/258
-
7/25/2019 170112 - Purin Synthesis
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JC$ # # (>L rn 8
-
7/25/2019 170112 - Purin Synthesis
186/258
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7/25/2019 170112 - Purin Synthesis
187/258
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7/25/2019 170112 - Purin Synthesis
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_0# O vP ]# B[ = /Hu T
#L G X ! * ai) # = 3 ##6 BI t8 , N5#N / # 2R 1 f$T # * I #1 #^ * = # : $a R # # #L .>- $ ## I d #Q *
< 6 a G ,d dA#F
-
7/25/2019 170112 - Purin Synthesis
200/258
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7/25/2019 170112 - Purin Synthesis
201/258
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P # ### #Z # I'R ## B+#? /#n (##&1 @ # # A J2#b / 0 #2 : ?E bPR 2
V#O M'b .5##### #8 i^6 # # 1 F Q # # : Z ]
-
7/25/2019 170112 - Purin Synthesis
204/258
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7/25/2019 170112 - Purin Synthesis
205/258
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7/25/2019 170112 - Purin Synthesis
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7/25/2019 170112 - Purin Synthesis
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X $P$C T [(G## _':Pn Q U "s $# 0 #=\ M
-
7/25/2019 170112 - Purin Synthesis
208/258
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7/25/2019 170112 - Purin Synthesis
209/258
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7/25/2019 170112 - Purin Synthesis
210/258
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7/25/2019 170112 - Purin Synthesis
211/258
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#7 'L$ J 0G G T X## r nS# \ Q # 9# T 1 X D #%Vj 3# ) # Rt > # # M V$ A N O X[ # S-% U# I6NN ##X # 5
=# 6 9# x/ T #, ` # S$ # 8 ( 5 !#5s ?M , P \ H ##s dQ_*# # @ 9 U #&5A r Q^1 ## r-I _ +* n # # < # " > C#j1 sj s \ = > > & r , 5## # T #!R-
@2_ # ! !# 7?# X^G iS\i(U #1
-
7/25/2019 170112 - Purin Synthesis
216/258
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7/25/2019 170112 - Purin Synthesis
217/258
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V#' 66i /# $3 7OL ,#U
-
7/25/2019 170112 - Purin Synthesis
225/258
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226/258
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7/25/2019 170112 - Purin Synthesis
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R . # d `# O"2# 8 @ > # i q TC &+#JJ - Q b : Z r r ! I X4 a+ sa.J # J # 7 2 X#) Ttd ]5 E.G #%( sZ ( ### # D
###%H#J # # #+ # # L # _FF J 1 #T T I R O#A x#d- #9 ( # _ # # [ # I ' 6 a+ #2] , . ##D VI U ] H!X / ## 3 S ' s 0## r# D X eA f i H#$B# dT =U 5O\L \## 6R 6 ]OV2& # , #? # i U # 1 n G & g
#?$ / #n #X =
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7/25/2019 170112 - Purin Synthesis
230/258
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7/25/2019 170112 - Purin Synthesis
231/258
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7/25/2019 170112 - Purin Synthesis
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7/25/2019 170112 - Purin Synthesis
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#-Nxq M q>% # + 9
-
7/25/2019 170112 - Purin Synthesis
238/258
S # +V , # + A # G # r P. #H# = 9 -
-
7/25/2019 170112 - Purin Synthesis
239/258
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7/25/2019 170112 - Purin Synthesis
240/258
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7/25/2019 170112 - Purin Synthesis
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QR bD# b # + # + ## #C \V #B IJ#D#=%
-
7/25/2019 170112 - Purin Synthesis
243/258
x,& 3]# P##C 4# 9] f] ` sX S# !
-
7/25/2019 170112 - Purin Synthesis
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7/25/2019 170112 - Purin Synthesis
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`. $D# # # #6 x _& & # # 6* P r2D #i +Bf# # #I1 4 # 5 7y# # 5 j. ] # A/ 1# P?#D G r_Z ### # ! ## #Cs * [Dr# %>"# .#a ] NT(f# x6 # # ## # #Xrb a V =H # y O # ## # / \ H: SR R# # b ## 0I # #L ## / bF 8 C z{ @& M# L # 4# #4 Td5 D e#! O C #M%8 ' ## P9 6
-
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" T 2 #AJ ## @ .
-
7/25/2019 170112 - Purin Synthesis
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7/25/2019 170112 - Purin Synthesis
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## J#[ # S %/ F# 8 # Q x 0
-
7/25/2019 170112 - Purin Synthesis
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