bioginkgo 27/7
DESCRIPTION
BioGinkgo 27/7. Proprietary extract of ginkgo leaves Addresses #2 concern among aging baby boomers Loss of memory. A 100 Yr. Old Bonsai Ginkgo Tree. Ginkgo biloba L. plant: History. Oldest living plant species, nick named “living fossil”. In China, it is called “thousand-year-old tree” - PowerPoint PPT PresentationTRANSCRIPT
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BioGinkgo 27/7BioGinkgo 27/7
A 100 Yr. Old Bonsai Ginkgo Tree
Proprietary extract of ginkgo leaves
Addresses #2 concern among aging baby boomers Loss of
memory
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Ginkgo biloba L. plant: HistoryGinkgo biloba L. plant: History Oldest living plant species, nick named “living
fossil”. In China, it is called “thousand-year-old tree”
Described in the ancient Chinese pharmacopoeia- Shen nown Ben Cao
Since 1960s, Ginkgo biloba extract is the most widely used herb in Europe
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Ginkgo biloba L. leaf: History, Ginkgo biloba L. leaf: History, cont’dcont’d
Pharmanex scientific advisor, Prof. Koji Nakanishi, Columbia University: Discovered a class of unique ginkgolides in ginkgo plant
Ginkgolides can increase blood flow by blocking PAF, a substance that causes platelet clumping
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BioGinkgo 27/7: UniquenessBioGinkgo 27/7: Uniqueness
Pharmanex extraction process enriches for ginkgolides
Only Ginkgo extract that provides for adequate and persistent amounts of ginkgolides in the blood
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30 minutes
Gin
kg
olid
e le
ve
ls (
µg
/ml) BioGinkgo 27/7
Ginkoba
12 hours
Blood concentration of ginkolides after Blood concentration of ginkolides after oral intake of BioGinkgo 27/7 or Ginkobaoral intake of BioGinkgo 27/7 or Ginkoba
Published in Planta Medica
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BioGinkgo 27/7 - AttributesBioGinkgo 27/7 - Attributes
Unique formulation of enriched for levels of ginkgolides
Improved bioavailability compared to competitors
Undesirable Ginkgolic acids removed One of the few companies to
manufacture its own ginkgo product
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Bioginkgo 27/7 process schemeBioginkgo 27/7 process scheme
Finished bulk preparation
Selected leaves
1. crushed
2. aq. Alcohol extract
3. precipitation
4. chromatography
5. remove Ginkgolic acids
6. drying
Flavone-lactone mixture
QA/QC
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Chemical fingerprint of Chemical fingerprint of ginkgolide terpene lactonesginkgolide terpene lactones
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Ginkgo biloba Extract: Cerebral Ginkgo biloba Extract: Cerebral InsufficiencyInsufficiency
Taillander et al. Presse Med. 1986 15 1583-1587 12-month placebo controlled trial of 210 elderly patients Ave. age 82 years End points: Symptoms scale including dizziness, tinnitus, headaches, lack of
energy, and difficulties in memory and concentration at 3, 6, 9, and 12 months
Time of assessment
Treatment 3 6 9 12 months
Placebo 4% 4% 8% 8% Ginkgo 10% 15% 15% 17%
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JAMA clinical studyJAMA clinical study
A Placebo-Controlled, Double-blind, Randomized Trial
A 52-week multi-center study Patients: Outpatients with Alzheimer
disease or multi-infarct dementia, without other significant medical conditions.
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JAMA clinical study: Study JAMA clinical study: Study DesignDesign Complete outcome evaluation at 12, 26,
and 52 weeks. Primary Outcome Measures.
Alzheimer's Disease Assessment Scale-Cognitive subscale (ADAS-Cog), Geriatric Evaluation by Relative's Rating Instrument (GERRI), and Clinical Global Impression of Change (CGIC).
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JAMA clinical study: JAMA clinical study: ConclusionsConclusions
Ginkgo group score better than placebo in ADAS-Cog and GERRI score
No difference in the Clinical Global Assessment Index Ginkgo was safe Appears capable of stabilizing and improving the
cognitive performance and the social functioning of patients for 6 months to 1 year.
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BioGinkgo 27/7: summaryBioGinkgo 27/7: summary
BioGinkgo enhances blood circulation to brain, arms, legs
Mechanism of action believed to be related to flavonoids and ginkgolides
BioGinkgo is recommended to be taken one tablet twice a day
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Introducing…Bio St. John’sIntroducing…Bio St. John’s
Standardized St. John’s wort to 0.3% hypericin(Hypericum perforatum)
PLUSCordyMax Cs-4 [Patent Pending]
(Cordyceps sinensis)
Each capsule of Bio St John’s contains 375 mg of CordyMax and 225 mg St John’s wort extract.
The daily recommended dosage is two capsules twice a day.
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Bio St. John’s : ClaimsBio St. John’s : Claims
Stabilizes mood and promotes a positive outlook
Provides vitality and stamina Reduces fatigue without stimulants
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Bio St. John’s: BenefitsBio St. John’s: Benefits
Bio St. John’s is not a substitute for prescription anti-depressant drugs
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St. John’s Wort: Brit. Medical St. John’s Wort: Brit. Medical Journal StudyJournal Study
Meta-Analysis (BMJ, 1996) 23 randomized trials with 1,757 patients
% patients respond to treatment SJW (55.1%) vs Placebo (22.3%) SJW (63.9%) vs Antidepressant (58.5%)
Test on mild/moderate depression major depression or manic depressive
disorder not tested
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Putative mechanisms of actionPutative mechanisms of action
Monoamine oxidase inhibition Selective serotonin-reuptake inhibition Inhibition of catechol O-methyltransferase GABA and neurokinin receptors
Overall outcome: Effect on neurotransmitters function
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St. John’s wort : Safety/Possible St. John’s wort : Safety/Possible side effectsside effects
Most common adverse effects are: GI symptoms Tiredness/sedation Dizziness/confusion Photosensitivity, but this appears to
occur rarely
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Before St.John’s wortAfter St.John’s wort
Age
Efficacy with ageEfficacy with age
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Bio St. John’sBio St. John’s
A combination of St. John’s wort and CordyMax
The recommended dose for Bio St John’s is 4 capsules daily
It is not a replacement for prescription anti-depressants